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. Author manuscript; available in PMC: 2016 Nov 23.
Published in final edited form as: Nature. 2016 May 23;534(7605):115–118. doi: 10.1038/nature17955

Figure 3. Memories are contextually linked but distinct.

Figure 3

a, Design for transfer of fear experiment. b, There was a significant difference in freezing (one-way ANOVA, F2,47=4.62, p=0.01, n=18,17,15). There was no difference between freezing in contexts C and B (t45=0.42, n.s.). Animals had less freezing in context A than C (t47=2.46, p=0.02) and B (t47=2.83, p=0.007). c, Design for extinction experiment. d, There was a significant difference in freezing during the context test (one-way ANOVA, F2,57=12.99, p<0.0001, n=20,20,20). There was no difference between freezing in contexts C and B (t57=0.80, n.s.). Animals had less freezing in context D than C (t57=4.76, p<0.0001) and B (t57=3.96, p=0.0002). e, There was a significant difference in freezing during the extinction test (one-way ANOVA, F2,57=4.79, p=0.01, n=20,20,20). There were no differences in freezing between groups B and D (t57=0.81, n.s.). Group C had less freezing than groups B (t57=2.18, p=0.03) and D (t57=2.99, p=0.004). f, Design for enhancement experiment. g, There was a significant difference in freezing (one-way ANOVA, F2,51=9.63, p<0.001, n=14,20,20). The 5h group had more freezing than the home cage (HC) (t51=3.98, p=0.0002) and 7d (t51=3.45, p=0.001) groups. There was no difference between HC or 7d groups (t51=0.86, n.s.). Significance: *p<0.05, **p<0.01. Results show mean +/− sem.