Table 1.
Clinical Characteristics of the Study Population with Resectable Disease (n = 30) Stratified according to Pulmonary Vein and Peripheral Vein CTC Status
| Strata | All | Pulmonary Vein CTC Status |
p Value |
Peripheral Vein CTC Status |
p Value |
||
|---|---|---|---|---|---|---|---|
| High | Low | Positive | Negative | ||||
| Total | |||||||
| n (%) | 30 | 7 (23.3) | 23 (76.7) | — | 6 (22.2) | 21 (77.8) | — |
| Age | |||||||
| y ± SD | 67.5 ± 7.1 | 67.7 ± 10.6 | 67.5 ± 5.9 | 0.94 | 71.7 ± 8.8 | 65.9 ± 6.3 | 0.08 |
| Male sex | |||||||
| n (%) | 16 (53.3) | 4 (57.1) | 12 (52.2) | 0.82 | 4 (66.7) | 11 (52.4) | 0.66 |
| Smoking status (%) | |||||||
| Current | 16 (53.3) | 6 (85.7) | 10 (43.5) | 0.09 | 2 (33.3) | 12 (57.4) | 0.39 |
| Former | 14 (46.7) | 1 (14.3) | 13 (56.5) | 4 (66.7) | 9 (42.9) | ||
| Never | 0 | 0 | 0 | 0 | 0 | ||
| Smoking (± SD) | |||||||
| Age started | 15.2 ± 2.5 | 14.3 ± 1.4 | 15.5 ± 2.7 | 0.26 | 15.3 ± 1.9 | 15.1 ± 2.7 | 0.85 |
| Cigs/d | 23.2 ± 12.9 | 23.3 ± 12.2 | 23.2 ± 13.4 | 0.99 | 16.6 ± 10.1 | 25.4 ± 14.0 | 0.21 |
| Duration | 43.8 ± 12.8 | 51.1 ± 10.7 | 41.5 ± 12.7 | 0.08 | 45.5 ± 14.3 | 41.7 ± 12.5 | 0.53 |
| Pack-years | 51.8 ± 36.4 | 60.5 ± 32.9 | 48.8 ± 37.8 | 0.47 | 38.7 ± 29.3 | 54.6 ± 40.5 | 0.42 |
| FEV1 (± SD) | |||||||
| Liters | 1.91 ± 0.72 | 1.96 ± 0.42 | 1.89 ± 0.79 | 0.84 | 1.99 ± 0.83 | 1.82 ± 0.70 | 0.62 |
| %pred | 73.4 ± 20.3 | 79.0 ± 20.5 | 71.9 ± 20.5 | 0.50 | 71.0 ± 18.0 | 70.4 ± 19.4 | 0.95 |
| FVC (± SD) | |||||||
| Liters | 3.09 ± 0.82 | 3.28 ± 0.44 | 3.03 ± 0.90 | 0.53 | 3.38 ± 0.96 | 2.91 ± 0.68 | 0.20 |
| %pred | 98.1 ± 17.4 | 104.2 ± 16.1 | 96.5 ± 17.8 | 0.39 | 95.7 ± 13.2 | 96.0 ± 17.8 | 0.97 |
| FEV1/FVC | |||||||
| Ratio | 58.8 ± 17.8 | 59.8 ± 9.0 | 58.4 ± 20.2 | 0.87 | 56.8 ± 14.5 | 58.6 ± 19.9 | 0.86 |
| Alcohol | |||||||
| U/wk | 16.9 ± 35.6 | 8.3 ± 14.2 | 19.6 ± 40.0 | 0.47 | 3.7 ± 8.0 | 15.0 ± 31.1 | 0.39 |
| Pathological stage (%) | |||||||
| I | 12 (40.0) | 1 (14.3) | 11 (47.8) | 0.09 | 2 (33.3) | 10 (47.6) | 0.31 |
| II | 11 (36.7) | 5 (71.4) | 6 (26.1) | 1 (16.7) | 7 (33.3) | ||
| III | 7 (23.3) | 1 (14.3) | 6 (26.1) | 3 (50.0) | 4 (19.0) | ||
| IV | 0 | 0 | 0 | 0 | 0 | ||
| Disease (%) | |||||||
| Squam | 21 (70.0) | 5 (71.4) | 15 (65.2) | 0.25 | 5 (83.3) | 16 (76.2) | 0.88 |
| Adeno | 8 (26.7) | 1 (14.3) | 7 (30.4) | 1 (16.7) | 4 (26.1) | ||
| Tumor size | |||||||
| mm ± SD | 39.7 ± 29.2 | 45.6 ± 29.4 | 37.9 ± 29.6 | 0.55 | 52.5 ± 34.6 | 37.9 ± 28.5 | 0.30 |
| PET/CT | |||||||
| SUV | 12.0 ± 6.8 | 11.5 ± 5.3 | 12.1 ± 7.3 | 0.83 | 10.9 ± 5.1 | 13.0 ± 7.3 | 0.52 |
| Received Adj chemo | |||||||
| n (%) | 12 (40) | 2 (28.6) | 10 (43.5) | 0.67 | 3 (50.0) | 8 (38.1) | 0.66 |
| Experienced Recurrence | |||||||
| n (%) | 10 (33.3) | 4 (57.1) | 6 (26.1) | 0.18 | 4 (66.7) | 5 (23.8) | 0.14 |
| Dead | |||||||
| n (%) | 13 (44.8) | 4 (57.1) | 9 (40.9) | 0.67 | 4 (66.7) | 7 (35.0) | 0.35 |
Note: For pulmonary vein circulating tumor cell status, values of ≥18 CTCs per 7.5 mL of blood were considered high. For peripheral vein circulating tumor cell status, values of ≥1 CTCs per 7.5 mL of blood were assumed for +ve values.
CTC, circulating tumor cell; Cigs, cigarettes; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; U, unit(s); Squam, squamous cell carcinoma; Adeno, adenocarcinoma; PET/CT, positron emission tomography/computed tomography; SUV, standardized uptake value; Adj chemo, adjuvant chemotherapy.