Table 1.
Baseline clinical and demographic characteristics of patients who received cranial radiation therapy with CMBs compared with those without CMBs
|
CMBs
(n = 50) |
No CMBs
(n = 60) |
P-value a | |
|---|---|---|---|
| Female (%) | 26 (52) | 24 (48) | .577 |
| Race (%) | .51 | ||
| White | 40 (80) | 46 (77) | |
| Black | 4 (8) | 8 (13) | |
| Asian | 5 (10) | 3 (5) | |
| Other | 1 (2) | 3 (5) | |
| Age at radiation therapy, median (range) | 7.6 (1–21) | 9.6 (1–20) | .126 |
| Adjuvant chemotherapy (%) | 46 (92) | 46 (77) | .3 |
| Anti-angiogenic chemotherapy (%) | 7 (14) | 7 (12) | 1. |
| Cancer type (%) | .253 | ||
| Medulloblastoma | 19 (38) | 11 (19) | |
| Ependymoma | 9 (18) | 11 (19) | |
| Germinoma | 4 (8) | 7 (12) | |
| High grade glioma | 4 (8) | 8 (13) | |
| Low grade glioma | 4 (8) | 10 (17) | |
| Other | 10 (20) | 13 (22) | |
| Iron sensitive imaging (ISI) | .17 | ||
| (ISI) b (%) | 1 (2) | 6 (10) | |
| No ISS | 18 (36) | 32 (53) | |
| GRE/FFE | 31 (62) | 22 (37) | |
| SWI | |||
| Radiation (%) | .64 | ||
| Craniospinal or whole brain | 29 (60) | 23 (41) | |
| Tumor bed only | 20 (40) | 33 (59) | |
| Maximum brain radiation, cGy median (range) | 5580 (2400–6260) | 5400 (2700–6674) | .93 |
| VP shunt (%) | 16 (32) | 16(27) | .54 |
| Seizure disorder (%) | 8 (16) | 10 (13) | .925 |
| Surgical resection | 7 (12) | 7 (16) | .792 |
a P-values are Pearson’s chi-square test for categorical variables and the Mann‒Whitney U-test for continuous variables.
bISS, iron sensitive sequencing. ISI includes SWI and T2* susceptibility-weighted angiography, gradient-recalled echo (GRE), fast-field echo (FFE), and multiplanar gradient recalled imaging which utilize the difference in magnetic susceptibility of blood, iron, and calcification to detect the presence of iron with high sensitivity.