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Model of GPVI-Fc and Cross-Linked GPVI-Fc Binding to Plaque Collagen
Cross-linking of dimeric glycoprotein VI–fragment crystallizable (GPVI-Fc) fusion protein (GPVI, brown; Fc, blue) by anti–Fc Fab2 creates oligomeric (n = 2 to 4) GPVI-Fc molecules, which bind to their corresponding motifs on collagen fibers more densely (bottom) than GPVI-Fc (top).
