Table 4.
In vitro permeation parameters of 5-FU from optimized nanoemulsions (mean ± SD, n=3)
| Formulations | SSF (Jss) (μg/cm2/h) | CAP 12 hours (μg/cm2) | LT (hours) | CP (cm/h) |
|---|---|---|---|---|
| 5-FU-NLC gel | 10.27±1.82 | 92.45±4.85 | 1.92±0.132 | 6.24±2.84 |
| 5-FU plain gel | 2.85±1.12 | 23.26±2.64 | 0.85±0.154 | 1.85±0.86 |
Abbreviations: CAP, cumulative amounts of drug permeated; CP, permeation coefficient; 5-FU, 5-fluorouracil; Jss, drug flux at steady state; LT, log time; NLC, nanostructured lipid carrier; SD, standard deviation; SSF, steady-state flux.