Table 5.
Drug release kinetics parameters of 5-FU-NLC gel and 5-FU plain gel obtained from in vitro data on permeation through excised rat skin (mean ± SD, n=3)
| Batches | Zero order
|
First order
|
Higuchi
|
Korsmeyer–Peppas
|
||||
|---|---|---|---|---|---|---|---|---|
| K0 (μg/h) | R2 | K1 (h−1) | R2 | KH (h−0.5) | R2 | n | R2 | |
| 5-FU-NLC gel | 1.1240 | 0.8213 | 2.8324 | 0.8672 | 3.1280 | 0.9784 | 0.6450 | 0.9586 |
| 5-FU plain gel | 0.8726 | 0.6126 | 1.2483 | 0.8824 | 1.9240 | 0.8235 | 6.742 | 0.8972 |
Abbreviations: 5-FU, 5-fluorouracil; K0, zero-order release constant; K1, first-order rate constant; KH, Higuchi release constant; n, release exponent in Korsmeyer–Peppas model; NLC, nanostructured lipid carrier; R2, squared correlation coefficient; SD, standard deviation.