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. 2016 Oct 5;9:6037–6048. doi: 10.2147/OTT.S94531

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© 2016 Weisel. This work is published and licensed by Dove Medical Press Limited

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Dual mechanism of action of elotuzumab to induce myeloma cell death.

Notes: (A) Elotuzumab binds to SLAMF7 on myeloma cells, targeting them for ADCC-mediated destruction. Through the CD16 receptors, NK cells bind to the Fc part of elotuzumab and become activated, finally leading to ADCC. (B) Elotuzumab binds to SLAMF7 on NK cells, directly activating them and resulting in increased cytokine production and release of cytotoxic granules.

Abbreviations: ADCC, antibody-dependent cell-mediated cytotoxicity; EAT-2, Ewing’s sarcoma-associated transcript 2; NK, natural killer; SLAMF7, signaling lymphocytic activation molecule F7.