Table S2. Characteristics of studies included in the meta-analysis of colorectal endoscopic submucosal dissection.

Article	Data period, yr	Country	Patients, n	Age, mean (range), yr	Female, %	Tumor, n	Tumor size, mean (range), mm	Procedure length, mean (range), min
Kawaguti 2014 15	2008 – 2011	Brazil	11	62	NA	11	65	133
Santos 2013 16	2010 – 2011	Brazil	7	54 (45 – 60)	43	7	26 (20 – 50)	163 (80 – 242)
Wang 2014 17	NA	China	17	NA	NA	17	9.4 (7 – 25)	NA
Zhao 2012 18	2002 – 2008	China	10	NA	NA	10	NA	(16 – 35)
Hon 2011 19	2000 – 2010	China	14	65	64	14	29	78 (25 – 180)
Rahmi 20141 20	2010 – 2012	France	45	67	47	45	35 (10 – 100)	110 (30 – 280)
Farhat 20111 21	2008 – 2010	France	85	NA	NA	85	NA	NA
Probst 2012 22	2004 – 2011	Germany	76	64 (38 – 85)	43	82	45.5	176
Repici 2013 23	2010 – 2011	Italy	40	65 (43 – 83)	33	40	47 (33 – 80)	86 (40 – 190)
Fusaroli 2009 24	NA	Italy	8	64	63	8	42	110
Trecca 2014 25	2012 – 2013	Italy	14	(50 – 82)	57	14	3 (1.5 – 5.5)	123 (60 – 240)
Niimi 2010 26	2000 – 2008	Japan	290	65 (29 – 88)	68	310	29 (6 – 100)	NA
Nishiyama 2010 27	2001 – 2008	Japan	282	69 (30 – 91)	48	296	27 (4 – 75)	NA
Tamegai 2007 28	2003 – 2005	Japan	70	63	46	71	33 (13 – 80)	61 (7 – 164)
Hotta 2012 29	2000 – 2010	Japan	215	69	37	219	30 (6 – 100)	101 (20 – 595)
Ishi 2010 30	2005 – 2009	Japan	33	66 (42 – 89)	39	33	35 (20 – 80)	121 (22 – 240)
Imaeda 2012 31	2008 – 2010	Japan	13	69 (42 – 90)	31	13	33 (20 – 80)	60 (20 – 150)
Tanaka 2007 32	2003 – 2005	Japan	70	66 (36 – 85)	33	70	28	71 (15 – 180)
Onozato 2007 33	2002 – 2006	Japan	30	70 (51 – 89)	47	30	26 (8 – 60)	70 (8 – 360)
Sohara 2013 34	2006 – 2011	Japan	129	66 (44 – 80)	33	129	32 (2 – 92)	60 (7 – 300)
Hori 2014 35	2006 – 2010	Japan	242	70 (62 – 75)	32	247	35 (23 – 46)	60 (40 – 120)
Ohya 2009 36	2008 – 2009	Japan	45	71 (58 – 83)	NA	45	35 (13 – 98)	60 (12 – 200)
Fujihara 2013 37	2010 – 2012	Japan	68	71 (37 – 88)	43	68	35	105 (45 – 250)
Okamoto 2013 38	2010 – 2012	Japan	30	69 (63 – 76)	43	30	36 (28 – 45)	61 (58 – 72)
Akahoshi 2010 39	NA	Japan	10	66 (55 – 74)	40	10	NA	155
Shono 2011 40	2007 – 2010	Japan	137	67 (40 – 90)	42	137	29 (20 – 150)	79 (20 – 100)
Izumi 2014 41	2006 – 2011	Japan	199	66 (35 – 90)	40	199	35 (20 – 110)
Motohashi 2011 42	NA	Japan	12	NA	NA	12	(22 – 42)	45 (30 – 110)
Mizushima 20141 43	2009 – 2013	Japan	122	68 (38 – 91)	41	134	27 (5 – 65)	64 (8 – 189)
Takeuchi 20141 44	2007 – 2010	Japan	808	67	43	816	NA	78 (50 – 120)
Kita 2007 45	1998 – 2005	Japan	166	NA	NA	166	33	102
Homma 20121 46	2009 – 2010	Japan	100	71 (30 – 88)	48	102	32 (12 – 120)	54 (15 – 270)
Sato 2014 47	2009 – 2013	Japan	147	72 (37 – 89)	42	151	32 (20 – 85)	72 (15 – 340)
Shiga 2014 48	2009 – 2013	Japan	80	68.1	33	80	35	109
Sakamoto 2014 49	NA	Japan	1017	66	43	1017	38	103
Nagai 2012 50	2007 – 2011	Japan	139	(39 – 89)	35	140	NA	70 (15 – 350)
Ohata 2013 51	2007 – 2012	Japan	608	67	NA	608	36	69.5
Nawata 2014 52	2010 – 2013	Japan	150	69 (36 – 91)	39	150	30 (18 – 123)	43 (6 – 235)
Yoshida 2014 53	2010 – 2013	Japan	371	70 (35 – 92)	NA	371	30 (6 – 100)	59 (6 – 385)
Toyonaga 20101 54	2002 – 2008	Japan	512	NA	NA	512	29 (4 – 158)	57 (11 – 335)
Kim 2013 55	2005 – 2011	S.Korea	44	47	27	44	6	9.4
Lee 2010 56	2003 – 2009	S.Korea	46	49	54	46	6.2 (2 – 15)	18.9
Park 2012 57	2007 – 2011	S.Korea	30	59	53	30	25	84
Lee 2013 58	2005 – 2011	S.Korea	26	NA	15	26	6.2	22
Kim 2013 59	2007 – 2011	S.Korea	115	63 (31 – 87)	38	115	29 (10 – 64)	65 (6 – 220)
Lee 2013 60	2006 – 2011	S.Korea	974	61 (25 – 86)	NA	1000	24 (3 – 145)	49 (3 – 321)
Sohn 2008 61	2003 – 2006	S.Korea	41	53 (32 – 78)	46	42	4.4 (2 – 10)	7.8 (2 – 22)
Moon 2011 62	2007 – 2009	S.Korea	35	49 (32 – 74)	29	35	4.7 (1 – 9)	36 (7 – 82)
Jung 2013 63	2009 – 2011	S.Korea	82	59	46	82	27	52
Choi 2013 64	2008 – 2011	S.Korea	31	48	35	31	5.2	15
Byeon 2011 65	2004 – 2010	S.Korea	233	61	37	237	30	44.6
Spychalski 2014 66	2013 – 2014	Poland	70	67 (38 – 84)	57	70	34 (15 – 75)	106 (30 – 225)
Thorlacius 2013 67	2012 – 2013	Sweden	29	74 (46 – 85)	52	29	28 (11 – 89)	142 (57 – 291)
Hsu 2013 68	2010 – 2013	Taiwan	50	64 (46 – 82)	50	50	33 (12 – 70)	71 (16 – 240)
Tseng 2013 69	2006 – 2011	Taiwan	92	66	36	92	37	59
Hurlstone 2007 70	2004 – 2006	UK	42	68 (52 – 79)	36	42	NA	48 (18 – 240)
Lang 2014 71	2006 – 2013	USA	11	NA	NA	11	34 (10 – 50)	106 (16 – 166)
Kantsevoy 2014 72	2012 – 2013	USA	8	NA	63	8	NA	NA
Bassan 20122 73	2010 – 2011	Australia	104	NA	NA	104	38	95
Zhong 20132 74	2006 – 2011	China	255	NA	NA	255	NA	NA
Hon 20122 75	2009 – 2012	China	61	NA	NA	61	25	NA
Emura 20142 76	2008 – 2013	Colombia	32	NA	NA	32	33	109
Kruse 20122 77	2006 – 2011	Germany	81	69 (47 – 90)	31	83	NA	NA
Sauer 20142 78	2012 – 2013	Germany	81	NA	NA	83	35	103 (20 – 600)
Iacopini 20142 79	2009 – 2013	Italy	112	NA	NA	112	NA	NA
Trentino 20102 80	NA	Italy	14	NA	NA	14	28	NA
De Lisi 20122 81	NA	Italy	11	71	64	11	24 (10 – 40)	137 (45 – 270)
Petruzziello 20142 82	2011 – 2013	Italy	15	65 (40 – 77)	33	15	23	70
Andrisani 20142 83	2011 – 2013	Italy	30	NA	NA	30	29	71
Kaneko 20132 84	2001 – 2012	Japan	16	NA	NA	16	6.6	NA
Kudo 20132 85	2001 – 2012	Japan	485	NA	NA	485	NA	NA
Mizuno 20132 86	2005 – 2009	Japan	227	NA	NA	236	NA	NA
Osuga 20122 87	NA	Japan	13	NA	NA	13	NA	NA
Kashida 20122 88	NA	Japan	74	68	38	76	38
Kawazoe 20112 89	2006 – 2011	Japan	114	NA	NA	114	NA	NA
Nemoto 20142 90	2013	Japan	33	NA	NA	33	28 (15 – 67)	53 (26 – 247)
Hayashi 20132 91	2010	Japan	214	NA	NA	214	NA	NA
Inada 20132 92	2006 – 2012	Japan	502	NA	NA	502	31	94.9
Mitani 20132 93	2005 – 2011	Japan	647	66 (34 – 91)	36	748	32.9	68 (5 – 500)
Shiga 20102 94	2007 – 2010	Japan	32	70	56	32	27.4	70.9
Nio 20132 95	2008 – 2012	Japan	92	NA	NA	92	NA	NA
Sasajimi 20122 96	NA	Japan	150	NA	NA	150	33	86 (15 – 420)
Tanaka 20142 97	2009 – 2013	Japan	72	NA	NA	72	NA	NA
Yamamoto 20132 98	NA	Japan	61	NA	NA	61	31	65
Oyama 20102 99	NA…	Japan	148	NA	NA	148	31	NA
Horikawa 20122 100	2008 – 2012	Japan	83	NA	NA	83	NA	101
Kojima 20132 101	2007 – 2012	Japan	233	69 (33 – 87)	41	233	22	NA
Fukuzawa 20122 102	2007 – 2012	Japan	200	NA	NA	200	NA	100
Yamada 20132 103	2009 – 2012	Japan	92	NA	NA	92	34	65
Kobayashi 20122 104	2005 – 2011	Japan	71	NA	NA	71	29	141
Hayashi 20132 105	2010 – 2013	Japan	247	NA	NA	247	NA	79
Lee 20112 106	2004 – 2010	S.Korea	45	64 (26 – 85)	36	45	35	NA
Ko 20092 107	2004 – 2008	S.Korea	95	NA	NA	95	29 (12 – 86)	77
Park 20122 § 108	2009 – 2011	S.Korea	59	NA	NA	61	20 (5 – 50)	74 (11 – 280)
Kim 20102 109	NA	S.Korea	7	63	43	7	2.7	NA
Rhee 20102 110	2008 – 2010	S.Korea	78	NA	NA	80	27	50 (11 – 152)
Joo 20102 111	2007 – 2009	S.Korea	10	62 (50 – 75)	60	10	43	99 (22 – 246)
Bialek 20122 112	2006 – 2012	Poland	45	64 (49 – 85)	47	47	26 (10 – 60)	NA
Hulagu 20112 113	2007 – 2010	Turkey	17	NA	29	17	NA	NA
Tholoor 20122 114	2006 – 2011	UK	66	69	68	66	NA	NA
George 20132 115	2004 – 2012	UK	38	NA	NA	38	41 (15 – 100)	NA
Gorgun 20132 116	NA	USA	8	66 (50 – 88)	63	8	NA	126 (62 – 196)
Omer 20122 117	2009 – 2011	USA	66	NA	NA	66	NA	NA
Antillon 20092 118	2006 – 2008	USA	86	NA	NA	86	42	NA

yr, year; n, number; mm, millimeter; min, minute; NA, not available

¹Multicenter studies

²Abstracts