Table 1.

Data Summary for Experiment 1 - Effects of varying doses of B on structural plasticity in PL

Treatment	Sham	100B	200B
Animals	10	6	6
Neurons	66	36	36
Neurons/animal	6–7	6	6
Laminae Analyzed	Layers 2 and 3	Layers 2 and 3	Layers 2 and 3
Spines	27,225	14,458	12,554
Overall Spine Density ± SEM	2.75 ± 0.06	2.63 ± 0.17	2.47 ± 0.12*
Thin Spine Density ± SEM	2.13 ± 0.06	2.03 ± 0.15	1.89 ± 0.12*
Mushroom Spine Density ± SEM	0.35 ± 0.02	0.34 ± 0.02	0.33 ± 0.02
Stubby Spine Density ± SEM	0.27 ± 0.02	0.25 ± 0.01	0.25 ± 0.01
Neurons/animal – dendritic arborization analysis	5–6**	4–5**	4–6**
Apical dendrite length	2819 ± 135	2467 ± 255	2164 ± 214*
Apical branch endings	15 ± 1.1	14 ± 1.2	14 ± 0.7
Basal dendrite length	617.8 ± 45	568.4 ± 56	519.8 ± 50
Basal branch endings	4.9 ± 0.46	4.5 ± 0.38	4.46 ± 0.38

^*Indicates significant difference (p < 0.05) when compared to control treatment group.

^**Due to strict inclusion criteria (see Methods), the number of neurons analyzed in the dendritic arborization analysis is smaller than the number of neurons analyzed in the dendritic spine analysis.