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. Author manuscript; available in PMC: 2017 Oct 13.
Published in final edited form as: Curr Biol. 2016 Apr 13:S0960-9822(16)30179-8 10.1016/j.cub.2016.02.068. doi: 10.1016/j.cub.2016.02.068

Figure 1. Experimental scheme.

Figure 1

(A) Knock-in mice with a Glu1179Lys mutation in exon 19 of the Gnptab gene were constructed on a BALB/c background. Recordings were performed on mice pups separated from dam for recording on postnatal day 3, 5 and 8. (B) Frequency distribution of mouse pup vocalizations on day 8 in wild type littermates from the Gnptab wt/wt mice (green, n=20) and Gnptab mut/mut mice (red, n=19) (C) Sonogram of a wild type mouse pup vocalizing in isolation. Lower window is an expanded version of one portion, showing the repeated structure in the mouse vocalizations. Red bars indicate a detected vocalization. (D) Sonogram of a Gnptab mut/mut as in c. See also Figure S1.