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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Ann N Y Acad Sci. 2016 Jul 6;1378(1):68–79. doi: 10.1111/nyas.13120

Figure 2.

Figure 2

Long-term EEG/video recordings reveal delayed seizures and death after TMDT injection with DZP posttreatment. (A) This mouse was injected with 0.4 mg/kg TMDT and, with the occurrence of the first clonic seizure, received 5 mg/kg of DZP IP. Both EEG and motor activity were continuously recorded from before the TMDT injection through death approximately 9 h after TMDT administration. EEG recordings document ictal activity of a clonic seizure transitioning into a tonic–clonic seizure (arrowhead), which ended lethally. Motor convulsions ceased to be present at the arrow. Please note high-amplitude discharges associated with tonic–clonic seizure (actually preceding the seizure by several seconds). Decreasing amplitude of EEG discharges was associated with diminishing motor activity ending lethally. (All calibrations 1 mV; time mark 2 s). (B) This mouse was also injected with 0.4 mg/ kg TMDT and, with the occurrence of the first clonic seizure, received 1 mg/kg of MK-801 IP. The EEG shown here was recorded at the corresponding time after TMDT injection as in Fig. 2A. However, the EEG of the mouse posttreated with MK-801 shows only individual discrete interictal discharges (some marked with arrows) without any behavioral correlates. The mouse survived 24 h of recording. (All calibrations 0.5 mV; time mark 2 s). From Ref. 42.