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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Hypertension. 2016 Sep 12;68(5):1191–1199. doi: 10.1161/HYPERTENSIONAHA.116.07709

Figure 3. Activation of SIRT1 attenuated arterial stiffening and hypertension in KL+/− mice without affecting levels of circulatory Klotho.

Figure 3

(A) PWV and (B) Systolic BP in KL+/− mice. (C) Direct BP measured by intra-arterial cannulation under anesthesia. (D) Representative western blot bands and quantitative analysis of plasma Klotho. Protein expression was normalized to the loading control, and the relative expression calculated as the fold change relative to the experimental control (WT+ Saline). n=10–12 animals/group. Data=means±SEM. *P<0.05, ** P<0.01, ***P<0.001 vs. WT + Saline; +P<0.05, ++ P<0.01, +++P<0.001 vs. KL+/− + Saline.