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Possible modulation of the hepatic expression of IGF-I gene. GH and insulin may directly induce the transcription of IGF-I gene, but for that, glucose uptake and metabolization by the liver is needed. Hepatic glucose metabolism may directly induce the transcription of IGF-I gene. In addition, liver uptake of some amino acids, induced by GH or insulin, facilitates IGF-I expression, because these amino acids stabilize the IGF-I mRNA.
