Figure 9.

GH and GHR are expressed in NSCs from mice. NSCs obtained from nine-day-old mice cultured in proliferation media, free of GH, form neurospheres in which confocal microscopy immunoreactivity for SOX2 in the nuclei indicate that these cells are in an early phase of self-renewal. These cells show high immunoreactivity (green labeling) for GH (left) and its receptor (right), indicating that both GH and GHR are expressed in NSCs. Magnification: 40×. © 2012 Devesa J, Devesa P, Reimunde P, Arce V. Published in Growth Hormone and Kynesitherapy for Brain Injury Recovery³⁴³ under CC BY 3.0 license. Available from: http://dx.doi.org/10.5772/26998.

Abbreviation: NSCs, neural stem cells.