Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Oct 14;10:514. doi: 10.3389/fnhum.2016.00514

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016 Kravitz, O'Neal and Friend.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Basal ganglia circuitry in lean and obese conditions. (A) Striatal neurons send projections to the midbrain via the direct pathway or indirect pathway. Schematic is replicated in lean (left) and obese (right) conditions, to show reported dopaminergic alterations in obesity. Inlay: Dopaminergic synapse onto striatal iMSNs. GPe, globus pallidus; STN, subthalamic nucleus; SNr, substantia nigra; VTA, ventral tegmental area. (B) Hypothetical progression by which diet induced obesity is associated with impaired striatal dopamine transmission, leading to physical inactivity.