Table 6.
Summarizing table based upon final categorization.
| Histopathological categories (Table S3 in Supplementary Material) | Pharmacological categories (Table S4 in Supplementary Material) | Final categories (Table 1) | ||
|---|---|---|---|---|
| TN | 143 | 192 (47a) | 204 | No preneoplastic signals in subchronic studies, no pharmacological signals, no carcinogenicity |
| TP | 31 | 62 (5a) | 67 | Preneoplastic signals in subchronic studies, pharmacological signals, carcinogenicity |
| FN | 96 | 17 | Not conclusive | |
| FP | 19 | 1 | ||
| NT | 21 | |||
| NC | 14 | |||
| Total | 289 | 289 | 289 |
aSingle-in-class decisions.
NC, non-categorizable based on pharmacological target; NT, non-mammalian target in mammalian tissue; FN, false negative; FP, false positive; TN, true negative; TP, true positive.