Table 3.

Changes (mean and SE) in cognitive scores from phase 3 to phase 5 by sex, age group and APOE-ε4 carrier status

Sex	Cognitive test	APOE	Mean change (SE) by age at phase 5
			45–49	50–59	60–69
Men	Memory	Non-ε4	1.37 (0.15)	1.41 (0.10)	0.96 (0.16)
		ε4	1.67 (0.20)	1.44 (0.17)	0.76 (0.25)
	AH4	Non-ε4	1.54 (0.35)	1.48 (0.24)	0.53 (0.34)
		ε4	1.03 (0.42)	2.00 (0.39)	0.95 (0.59)
	Mill Hill	non-ε4	0.48 (0.11)	0.25 (0.08)	0.03 (0.13)
		ε4	0.26 (0.18)	0.43 (0.11)	0.33 (0.18)
	Phonemic fluency	non-ε4	0.83 (0.21)	0.55 (0.15)	−0.32 (0.21)
		ε4	0.88 (0.29)	0.62 (0.23)	0.12 (0.39)
	Semantic fluency	non-ε4	1.40 (0.17)	0.95 (0.14)	0.45 (0.19)
		ε4	1.29 (0.32)	1.06 (0.22)	0.60 (0.29)
Women	Memory	non-ε4	1.80 (0.33)	1.07 (0.19)	1.34 (0.26)
		ε4	1.84 (0.46)	1.07 (0.31)	0.57 (0.46)
	AH4	non-ε4	1.42 (0.58)	1.82 (0.44)	1.36 (0.52)
		ε4	1.32 (0.87)	1.85 (0.91)	0.39 (1.33)
	Mill Hill	non-ε4	0.53 (0.23)	0.31 (0.16)	0.55 (0.19)
		ε4	0.84 (0.31)	0.78 (0.32)	0.13 (0.34)
	Phonemic Fluency	non-ε4	0.44 (0.40)	0.76 (0.30)	−0.01 (0.43)
		ε4	0.45 (0.58)	−0.08 (0.50)	−0.03 (0.49)
	Semantic Fluency	non-ε4	2.31 (0.42)	1.66 (0.28)	0.86 (0.27)
		ε4**	0.58 (0.74)*	0.75 (0.30)	−0.31 (0.51)*

^*p=0.030 and 0.040 for semantic fluency score (age groups 45–49 and 60–69)

^**p=0.001 with age adjustment.