Table 1.
Unstressed | Stressed | 2‐way ANOVA | |||||
---|---|---|---|---|---|---|---|
Control | Restricted | Control | Restricted | Group | Stress | Interaction | |
Body weight (g) | |||||||
Postnatal day 1 | 4.32 ± 0.04 | 3.62 ± 0.05γ | |||||
Postnatal day 7 | 10.8 ± 0.3 | 8.8 ± 0.3γ | |||||
Postnatal day 14 | 23.3 ± 0.4 | 20.1 ± 0.6γ | |||||
Postnatal day 35 | 78 ± 1 | 72 ± 2γ | |||||
4 months | 219 ± 3 | 210 ± 2γ | |||||
Post‐pregnancy body weight (g) | |||||||
7 months | 268 ± 5 | 250 ± 5 | 267 ± 4 | 260 ± 3 | P = 0.006 | NS | NS |
9 months | 262 ± 3 | 247 ± 4 | 259 ± 3 | 254 ± 3 | P = 0.006 | NS | NS |
12 months | 271 ± 3 | 252 ± 3* | 264 ± 3 | 261 ± 3 | P = 0.001 | NS | P = 0.02 |
Post‐mortem (13 months) | 270 ± 4 | 258 ± 4 | 264 ± 4 | 261 ± 3 | P = 0.03 | NS | NS |
Organ weights (% BW) | |||||||
Pancreas | 0.299 ± 0.014 | 0.295 ± 0.015 | 0.321 ± 0.016 | 0.323 ± 0.020 | NS | NS | NS |
Liver | 2.81 ± 0.07 | 2.85 ± 0.06 | 2.81 ± 0.06 | 2.84 ± 0.05 | NS | NS | NS |
Dorsal white adipose tissue | 1.52 ± 0.07 | 1.57 ± 0.09 | 1.59 ± 0.12 | 1.42 ± 0.05 | NS | NS | NS |
Heart | 0.368 ± 0.003 | 0.367 ± 0.003 | 0.367 ± 0.005 | 0.374 ± 0.003 | NS | NS | NS |
Kidneys | 0.614 ± 0.009 | 0.600 ± 0.006 | 0.613 ± 0.006 | 0.609 ± 0.010 | NS | NS | NS |
Adrenals | 0.0212 ± 0.0005 | 0.026 ± 0.0010 | 0.0209 ± 0.0009 | 0.0214 ± 0.0003 | NS | NS | NS |
Effects of growth restriction and maternal stress on body weights and organ weights relative to body weight (mean ± SEM; n = 10–14 per group). γ P < 0.05 vs. Control; * P < 0.05 vs. Control counterpart (following significant interaction); NS, not significant.