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Skeletal muscle-specific knockdown of GRK2 in MLC-Cre:GRK2fl/fl mice. GRK2 protein levels were measured via Western blot in lysates from gastrocnemius (A), soleus (B), EDL (C), and heart (D). GAPDH levels were assessed as a loading control. Bars depict the mean signal intensity of GRK2 normalized to GAPDH, and error bars represent S.D. **, p < 0.01; ***, p < 0.001 between GRK2fl/fl and MLC-Cre:GRK2fl/fl animals; n = 4 and 5 per group, respectively. A.U., arbitrary units.
