TABLE 1.

Clenbuterol stimulated skeletal muscle hypertrophy is enhanced by skeletal muscle specific GRK2 knockdown

Data (mean ± S.E.) shown for 10–11 mice per group. BW, body weight; TA, tibialis anterior.

Measurement	GRK2fl/fl			MLC-Cre:GRK2fl/fl
	PBS	Clenbuterol	-Fold	PBS	Clenbuterol	-Fold
BW gain (g)	1.03 ± 0.25	2.17 ± 0.16a	2.11 ± 0.15	0.82 ± 0.3	2.33 ± 0.14a	2.83 ± 0.17c
EDL weight (mg/g BW)	0.39 ± 0.01	0.39 ± 0.02	1.0 ± 0.05	0.38 ± 0.01	0.42 ± 0.01	1.11 ± 0.03
TA weight (mg/g BW)	1.87 ± 0.04	2.02 ± 0.05	1.08 ± 0.03	1.87 ± 0.05	2.15 ± 0.04a	1.15 ± 0.02
Soleus weight (mg/g BW)	0.32 ± 0.01	0.37 ± 0.01a	1.15 ± 0.03	0.32 ± 0.01	0.41 ± 0.01a,b	1.31 ± 0.02c
Gastroc weight (mg/g BW)	2.83 ± 0.06	2.91 ± 0.09	1.03 ± 0.03	2.74 ± 0.06	3.17 ± 0.08a	1.16 ± 0.03c

^a p < 0.01 by ANOVA; PBS vs. clenbuterol (same genotype).

^b p < 0.01 by ANOVA; GRK2^fl/fl clenbuterol vs. MLC-Cre:GRK2^fl/fl.

^c p < 0.01 by Student's t test; -fold GRK2^fl/fl vs. -fold MLC-Cre:GRK2^fl/fl.