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A RUNX1 inhibitor protects against LPS-induced septic shock in vivo. LPS (20 mg/kg) was used to induce septic shock in C57BL/6 mice in the presence or absence of the RUNX1 inhibitor, Ro 5-3335. The survival rates of these mice were recorded (A), and the Il-6 mRNA levels in the kidneys were detected by RT-qPCR (B). The data are shown as the mean ± S.D. of three independent experiments. *, p < 0.05; **, p < 0.01.
