FIGURE 8.

Resistance and elastance of lung airways in C57BL/6J wild-type (WT) versus SR-A1^−/− mice challenged with OVA and c-OVA. A and B, pulmonary function measured as airway hyperresponsiveness (A) and lung mechanics (B) were measured in mice in response to increasing doses of inhaled methacholine following exposure to nebulized OVA or c-OVA as described under “Experimental Procedures.” Results are from a single experiment. Treatment regime and genotype are indicated with n > 10 mice per group. Data were expressed per group as mean ± S.E.