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Model of endocytosis-resistant mutants of TIMP-3. TIMP-3 contains an extended region of basic residues, depicted as the blue area calculated with PyMOL qualitative vacuum electrostatics. This region includes Lys-26/Lys-45 (A) and Lys-42/Lys-110 (B), whose mutation to alanine reduced TIMP-3 binding to LRP1.
