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Domain-domain interactions in class A carbapenemases
| Enzyme | Domain interface surface area | Interdomain hydrogen bonds |
||
|---|---|---|---|---|
| Protein-protein | Water-mediateda | Total | ||
| Å2 | ||||
| GES-5 C69G | 3050 | 23 | 32 (11) | 55 |
| GES-5 | 2900 | 25 | 27 (10) | 52 |
| SME-1 | 2900 | 18 | 23 (8) | 41 |
| NMCA | 2850 | 17 | 23 (8) | 40 |
| SFC-1 | 2950 | 16 | 29 (12) | 45 |
a The total number of water molecules that interact with both domains is given in parentheses.
