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. 2016 Aug 29;291(42):22207–22217. doi: 10.1074/jbc.M115.703835

FIGURE 1.

FIGURE 1.

PAHSAs protect mice from DSS-induced colitis. A, schematic of the experimental treatment time course. B and C, body weight (BW) and body weight change in 8- to 10-week-old male C57Bl6 mice pretreated with either vehicle (VEH) or 5- + 9-PAHSAs by oral gavage for 3 days, followed by either 0% or 2% DSS water with continued vehicle or 5- + 9-PAHSA treatment for an additional 10 days. D, clinical colitis score measured daily throughout the 10 days of simultaneous DSS water and vehicle or PAHSA treatment. E and F, colon length was measured on day 10. TX, treatment. Data are means ± S.E. and representative of three independent cohorts (n = 8–12 mice/group). *, p < 0.05 versus vehicle; #, p < 0.05 versus vehicle + 2% DSS; repeated measures two-way ANOVA.