Skip to main content
. 2016 Jul 14;291(42):22288–22301. doi: 10.1074/jbc.M115.712703

FIGURE 1.

FIGURE 1.

Impaired vascular function and structure were improved by SAA, MET, or a combination. Isometric tension studies were performed in diabetic or non-diabetic ICR mice and aorta relaxation in response to endothelium-dependent ACh and endothelium-independent SNP. Data were representative of 6–10 mice per group (A). H&E-stained aortas in mice were examined at ×400 (B). Data were expressed as mean ± S.E. *, p < 0.05; **, p < 0.01 versus ND; #, p < 0.05 versus D; γ, p < 0.05 at the same dose points of ACh and SNP. ND, non-diabetic mice; D, diabetic mice; D+MET, diabetic mice treated with metformin; D+SAA, diabetic mice treated with SAA; D+MET+SAA, diabetic mice treated with SAA combined with metformin; ACh, acetylcholine; SNP, sodium nitroprusside.