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. 2016 Oct 12;7:13125. doi: 10.1038/ncomms13125

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Copyright © 2016, The Author(s)

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(a) Competitive transplantation strategy used to assess multi-lineage blood reconstitution levels from peripheral blood after 4, 8 and 16 weeks. (b,c) Within LKS, which contain all multipotent stem and progenitor cells in the BM, long-term multi-lineage HSC function is restricted to TMRM^low cells (LKS:TMRM^low) (n=8 for each condition; error bar: s.e.m.; t-student, ***P<0.001). (d,e) In the phenotypically defined ST-HSC compartment, stemness is restricted to TMRM^low cells (ST-HSC:TMRM^low) (n=9 for each condition; error bar: s.e.m.; t-student, **P<0.01). (d,f) In the phenotypically defined LT-HSC compartment, stemness is restricted to TMRM^low cells (LT-HSC:TMRM^low) (n=9 for each condition; error bar: s.e.m.; t-student, ***P<0.001).