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. 2016 Oct 14;22(38):8497–8508. doi: 10.3748/wjg.v22.i38.8497

Figure 2.

Figure 2

Effect of dietary ethanol or/and guanidinoacetate ingestion on liver histology. Hematoxylin-eosin stained images of livers from animals fed the following diets are shown: Pair-fed control (A); 0.36% guanidinoacetate (GAA) (B); ethanol (C); ethanol + 0.36% GAA (D). Scale bars = 50 microns. Limited macrosteatosis was observed following the ethanol diet while much more extensive macrosteatosis with a limited number of cells exhibiting microsteatosis and a couple of small lipogranulomas (arrows) are seen in the livers of animals on the ethanol + 0.36% GAA diet. The livers of the animals on the 0.36% GAA diet are similar to the control livers. PT: Portal triad; CV: Central vein.