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. 2016 Oct 14;22(38):8497–8508. doi: 10.3748/wjg.v22.i38.8497

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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Effect of dietary ethanol and/or guanidinoacetate ingestion on hepatic S-adenosylmethionine, S-adenosylhomocysteine and S-adenosylmethionine: S-adenosylhomocysteine ratio. Rats were fed the Lieber DeCarli control or ethanol diet with or without 0.36% GAA supplementation. After 6 wk of feeding, Hepatocellular SAM (A) and SAH (B) levels were determined by HPLC analysis as detailed in the “MATERIALS AND METHODS” section and (C) SAM:SAH ratio calculated. The data shown are mean ± SEM of 5 determinations. Values not sharing a common subscript letter are statistically different, P < 0.05 vs control. GAA: Guanidinoacetate; SAM: S-adenosylmethionine; SAH: S-adenosylhomocysteine.