Table 2.
Multivariate Cox regression analysis of factors predicting survival time of patients without regional lymph node and distant metastasis
| Variable | HR | 95%CI | P value |
| Sex (male vs female) | 1.312 | 0.784-2.159 | 0.354 |
| Pathologic T stage (T3-4 vs T1-2) | 1.226 | 0.817-2.657 | 0.012 |
| Lymphovascular invasion (yes vs no) | 1.413 | 0.716-1.971 | 0.241 |
| Perineural invasion (yes vs no) | 1.539 | 0.992-2.321 | 0.114 |
| EMVI (positive vs negative) | 3.071 | 2.784-5.754 | < 0.01 |
| c-MYC expression (low vs strong) | 1.138 | 1.003-2.421 | 0.032 |
| PCNA expression (strong vs low) | 2.582 | 1.748-4.373 | 0.003 |
| TIMP1 expression (low vs strong) | 2.643 | 1.869-5.821 | 0.021 |
| IHC panel (2-3 markers high vs 0-1 marker high) | 2.110 | 1.631-2.556 | < 0.01 |
EMVI: Extramural vascular invasion; IHC: Immunohistochemistry.