Table 5.
Associations between C6‐DC or C10‐OH/C8‐DC level and physiological measures following the control (C) and high‐fat, high‐calorie (O) diets and between response values (Δ)
| C6‐DC (Slope, SD, P, Q) | C10‐OH/C8‐DC (Slope, SD, P, Q) | |||||
|---|---|---|---|---|---|---|
| C | O | Δ | C | O | Δ | |
| Lipid profiling | ||||||
| P‐TG | 0.893 | 1.170 | 5.201 | −1.976 | 0.774 | 5.816 |
| 2.298 | 1.847 | 2.184 | 3.209 | 3.828 | 3.574 | |
| 0.6999 | 0.5302 | 0.0227 | 0.5420 | 0.8410 | 0.1124 | |
| 0.1589 | ||||||
| Clamp | ||||||
| Basal | ||||||
| B‐Glucose | −1.683 | −5.724 | −2.958 | −7.441 | −9.371 | −4.710 |
| 3.409 | 2.404 | 2.522 | 4.689 | 4.895 | 3.395 | |
| 0.6245 | 0.0226 | 0.2487 | 0.1211 | 0.0635 | 0.2392 | |
| 0.1848 | ||||||
| S‐Insulin | −113.9 | −45.45 | −16.15 | −257.4 | 64.69 | 47.87 |
| 77.68 | 96.33 | 70.67 | 102.1 | 225.3 | 114.1 | |
| 0.1512 | 0.6402 | 0.8210 | 0.0162 | 0.7760 | 0.6780 | |
| 0.1134 | ||||||
| P‐NEFA | 2775 | 138.1 | 801.9 | 5505 | 894.5 | 3793 |
| 992.8 | 602.5 | 978.8 | 1338 | 1169 | 1423 | |
| 0.0082 | 0.8200 | 0.4180 | 0.0002 | 0.4490 | 0.0114 | |
| 0.1148 | 0.0028 | 0.1596 | ||||
| HGP | 0.662 | 3.164 | 1.891 | −2.140 | 6.143 | 8.350 |
| 3.900 | 3.712 | 4.235 | 5.419 | 7.286 | 6.613 | |
| 0.8660 | 0.3994 | 0.6578 | 0.6950 | 0.4050 | 0.2140 | |
| Hepatic IR | −296.3 | −3561 | −125.2 | −397.3 | −353.2 | 681.8 |
| 224.6 | 336.6 | 268.9 | 315.9 | 760.8 | 416.6 | |
| 0.1956 | 0.2973 | 0.6440 | 0.2168 | 0.6454 | 0.1110 | |
| GOX | −11.80 | −3.977 | −10.08 | −14.41 | −0.277 | −12.05 |
| 6.210 | 5.189 | 5.197 | 8.846 | 10.78 | 8.477 | |
| 0.0654 | 0.4486 | 0.0608 | 0.1120 | 0.9796 | 0.1640 | |
| FOX | 7.191 | 5.105 | 6.744 | 6.254 | 7.978 | 7.003 |
| 3.567 | 2.203 | 2.627 | 5.190 | 4.642 | 4.322 | |
| 0.0513 | 0.0264 | 0.0148 | 0.2360 | 0.0945 | 0.1140 | |
| 0.1848 | 0.1589 | |||||
| Insulin‐stimulated | ||||||
| M‐value | 33.49 | 20.55 | 5.711 | 46.84 | 23.39 | 1.585 |
| 17.21 | 18.70 | 15.25 | 21.59 | 37.19 | 23.35 | |
| 0.0595 | 0.2793 | 0.7104 | 0.0367 | 0.5336 | 0.9463 | |
| 0.1713 | ||||||
| GOX | −1.617 | 5.470 | 1.158 | −2.194 | 23.63 | 12.30 |
| 7.505 | 6.240 | 6.853 | 11.41 | 12.31 | 11.49 | |
| 0.8310 | 0.3867 | 0.8670 | 0.8490 | 0.0630 | 0.2930 | |
| FOX | 2.189 | 1.103 | 0.904 | −1.085 | −0.947 | −1.110 |
| 3.222 | 2.237 | 2.642 | 4.930 | 4.599 | 4.451 | |
| 0.5020 | 0.6249 | 0.7350 | 0.8270 | 0.8380 | 0.8047 | |
| IVGTT | ||||||
| FPIR | −4457 | −1.4 E4 | −8198 | −1.0 E4 | −1.8 E4 | −1.3 E4 |
| 6603 | 1.0 E4 | 5370 | 9035 | 2.0 E4 | 8439 | |
| 0.5043 | 0.1780 | 0.1361 | 0.2615 | 0.3572 | 0.1193 | |
| Hepatic DI | −0.350 | 0.433 | −0.131 | 0.483 | −0.794 | −0.566 |
| 0.926 | 1.029 | 0.730 | 1.277 | 2.111 | 1.160 | |
| 0.7080 | 0.6770 | 0.8590 | 0.7080 | 0.7090 | 0.6290 | |
| Peripheral DI | 0.2370 | −0.119 | 0.267 | 0.192 | −3.438 | −1.464 |
| 0.9630 | 1.193 | 1.024 | 1.329 | 2.437 | 1.585 | |
| 0.8070 | 0.9210 | 0.7960 | 0.8860 | 0.1672 | 0.3620 | |
Data are presented as slope, SD, and P‐value. P‐values ≤0.05 are presented together with Q‐values, and P‐values ≤0.05 with corresponding Q‐values ≤0.1 are considered statistically significant. P‐values ≤0.05 and Q‐values ≤0.1 are marked in bold. Regression analyses were performed on the pooled data set of LBW and NBW individuals and were adjusted for age, BMI, and birth weight group. Abbreviations: See Table 1.