Table 5.

Proteins regulated by NFE2L2 or identified as interaction partners of NFE2L2

Uniprot ID	Protein name	FC	Pathway/Function (Annotation/Reference)	Match of predicted versus observed regulation (Y/N)
B1ATI0	ALDH3A2	2.1	Target of NFE2L2 regulon (Kwak et al., 2003), repair of lipidperoxides (Demozay et al., 2008)	Y
A2AMV3	AKR7A5	1.4	NFE2L2‐mediated oxidative stress response (IPA), repair of lipidperoxides (Li et al., 2006)	Y
Q5EBQ7	MSRA	1.4	Co‐cited transcription factor NFE2L2 (GePS), repair of oxidized cysteine residues (Styskal et al., 2013)	Y
A2A8C9	HSP40 (DNAJC11)	1.4	NFE2L2‐mediated oxidative stress response (IPA)	Y
Q3TXQ6	CAT	0.7	NFE2L2‐mediated oxidative stress response (IPA, GePS)	N
P08228	SOD1	0.6	NFE2L2‐mediated oxidative stress response (IPA, GePS)	N
Q91VS7	MGST1	1.3	NFE2L2‐mediated oxidative stress response (IPA, GePS), repair of lipidperoxides (Kelner et al., 2000)	Y
Q64435	UGT1A6	2.6	Co‐cited transcription factor NFE2L2 (GePS)	Y
O35728	CYP4A14	0.4	Co‐cited transcription factor NFE2L2 (GePS),microsomal FAO (Gambino et al., 2011)	N
Q8VCW9	CYP2A12	1.8	Target of the NFE2L2 regulona	Y
B6VGH4	CYP1A2	1.6	Target of the NFE2L2 regulona	Y
O35490	BHMT	1.9	Target of the NFE2L2 regulona	Y
Q543J0	UOX	0.7	Target of the NFE2L2 regulona	Y
O88833	CYP4A10	0.5	Target of the NFE2L2 regulona, microsomal FAO (Gambino et al., 2011)	N
Q8BJL4	LMAN2	1.6	Target of the NFE2L2 regulona	Y
Q9D8V0‐3	HM13	1.7	Target of the NFE2L2 regulona	Y
O88668	CREG1	0.5	Target of the NFE2L2 regulona	N
Q3TJI8	HSD11B1	2.0	Co‐cited transcription factor NFE2L2 (GePS), inactivates NFE2L2 (Kratschmar et al., 2012)	–
A1A4A7	PGAM5	0.5	Co‐cited transcription factor NFE2L2 (GePS), tethers NFE2L2 to mitochondria (Xue et al., 2015)	–

^aKwak et al. (2003), FC – fold change reflects the mean abundance of high fat‐fed mice divided by the mean abundance of control‐fed mice.