Figure 3.
Microbial responses to optimized faropenem-based regimens in a paucibacillary model. A, The experimental faropenem, linezolid, and moxifloxacin (FLM) regimen and high-dose moxifloxacin (FLMHi) plus ethambutol (EMB), as well as the standard therapy regimen, had killed Mycobacterium tuberculosis (Mtb) in the pediatric hollow fiber system model for intracellular tuberculosis systems below colony-forming unit (CFU)/mL assay limits, suggesting complete sterilization. B, The time to positivity (TTP) assay revealed that there was still bacterial growth with the FLM regimen and standard regimen; the former has statistically higher TTP compared with standard regimen at the end of experiment, suggesting better kill rates.