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. 2016 Oct 13;36(21):2656–2667. doi: 10.1128/MCB.00183-16

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Copyright © 2016 Loos et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 7 — Model for dynamics of Xic transcriptional states. (a) Xic can adopt two distinct transcriptional states. State 1 is permissive whereas state 2 is refractive to Xist upregulation upon differentiation. (b) Under serum-plus-LIF conditions, female XX ES cells show rapid switching between different states, whereas under 2i+LIF conditions, state-switching dynamics are reduced, leading to synchronization of states. Rex and Rnf12 overexpression forces cells to adopt one single transcriptional state. (c) Relative quantity of alleles adopting distinct combinations of transcriptional states.