FIG 2.

Overexpression of CD36 attenuated the fasting-induced steatosis, hypoglycemia, and depletion of hepatic glycogen. (A to D) Mice maintained on a chow diet were subjected to 6 h and 16 h of fasting before measurement of liver triglyceride levels (A), blood glucose (B), liver glycogen levels (C), and liver PAS staining (D). n = 4 for all groups. (E) Insulin- and glucose-stimulated glycogen synthesis rates in primary mouse hepatocytes. (F) Incorporation of [³H]glucose into hepatic glycogen during the euglycemic-hyperinsulinemic clamp. WT, n = 7; CD36Tg, n = 6. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ns, statistically not significant. The data are presented as means and SEM.