TABLE 1.
Serum biochemistry of WT, CD36Tg, and CD36Tg-plus-Dox mice fed chow diet or HFD for 19 weeks
| Parameter | Value for: |
|||||
|---|---|---|---|---|---|---|
| Chow diet-fed mice |
HFD-fed mice |
|||||
| WT (n = 5) | CD36Tg (n = 4) |
CD36Tg + Dox (n = 4) | WT (n = 7) | CD36Tg (n = 6) |
CD36Tg + Dox (n = 4) | |
| Total cholesterol (mg/dl) | 114.3 ± 16.2 | 114.6 ± 8.8 | 119.2 ± 9.3 | 129.4 ± 22.1 | 165 ± 15.6b | 137.9 ± 14.5 |
| Triglyceride (mg/dl) | 51.8 ± 10.2 | 49.9 ± 9.5 | 58.5 ± 4.4 | 75.2 ± 20.0c | 75.0 ± 7.7 | 75.2 ± 7.7 |
| Free fatty acids (μM) | 318.5 ± 86.9 | 294 ± 101.8 | 347.2 ± 151 | 496 ± 94.7d | 526.5 ± 158.9 | 698.1 ± 145.9 |
| ALT (U/liter) | 26.4 ± 5.0 | 30.7 ± 7.3 | 21.4 ± 12.8 | 65.2 ± 6.7d | 45.7 ± 17.4a | 82.5 ± 30.0 |
| AST (U/liter) | 62.9 ± 20.1 | 68.9 ± 10.7 | 71.0 ± 14.3 | 225.7 ± 38.8d | 166.4 ± 17.6a | 265.9 ± 65.1 |
| Fasting blood glucose (mg/dl) | 128.7 ± 17.2 | 143.8 ± 3.2 | 127.4 ± 14.2 | 187.9 ± 35.6c | 190.1 ± 24.2 | 183.9 ± 23.3 |
| Fasting insulin (ng/ml) | 0.4 ± 0.1 | 0.6 ± 0.5 | 0.4 ± 0.08 | 8.3 ± 4.08d | 12.4 ± 6.1 | 6.1 ± 2.0 |
a
P < 0.05 compared to the WT within the diet group.
b
P < 0.01 compared to the WT within the diet group.
c
P < 0.05 for WT mice fed an HFD compared to WT mice fed chow to validate the HFD model.
d
P < 0.01 for WT mice fed an HFD compared to WT mice fed chow to validate the HFD model.