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. 2016 Oct 13;9:97. doi: 10.3389/fnmol.2016.00097

Figure 2.

Figure 2

Differential effects on cell body size of ectopic expression of Dimm, dInR, and Dimm/dInR in Dimm positive neurons in the third instar larva. (A) ABLKs were analyzed in abdominal segments A1-A7 and no significant size change was detected. (B) Leucokinin neurons in the lateral horn (LHLKs) increased only after combined Dimm/dInR expression. (C,D) Corazonin-producing neurons (vCrz) in thoracic and abdominal segments (T2-A6) (shown in D after corazonin immunolabeling) displayed different growth phenotypes depending on segment. In most segments Dimm/dInR expression induced growth, whereas in some segments dInR alone also has this effect. (E) Cell bodies of PDF expressing neurons of abdominal ganglia (Abd PDF) increase in size after dInR and combined Dimm/dInR expression. (F,G) CCAP producing neurons in abdominal segments A-A5 (Ccap-Gal>GFP in F) increase in size only after Dimm expression (G). Data are presented as means ± S.E.M, n = 6–13 flies for each genotype from three independent crosses (*p < 0.05, **p < 0.01, ***p < 0.001 as assessed by unpaired Students' t-test or non-parametric Mann Whitney test when data was not normally distributed). Further images of neurons from these experiments are shown in Supplementary Figure 5.