Figure 6. Olfr1393 responds to chemicals with pre-constrained rings containing either ketones or alcohols.

(A) Chemical structures for the 8 identified ligands for Olfr1393 are represented in the inner two circles. The strongest ligands are found in the dark gray inner circle while the weaker ligands are found in the light gray middle ring. Examples of structurally similar chemicals that do not activate Olfr1393 are found in the outermost ring. A complete list of chemicals that did not activate Olfr1393 can be found in Supplemental Table 2. The activating chemicals are numbered 1–8 and correspond to the labeling in the table in (B).