Figure 4. Highest degree hubs identified by PyInteraph in the PSN of mGCAP1 (top panels) and nmGCAP1 (bottom panels) in their EF2^CaEF3^CaEF4^Ca (left), EF2^Mg (center) and EF2^MgEF3^Mg (right) forms.

Secondary structure is represented in grey cartoons, Ca²⁺ ions are shown as red spheres, Mg²⁺ ions are shown as green spheres, the myristoyl group is represented as teal sticks, Cα of degree 7 hub residues are represented in blue spheres, Cα of degree 8 hub residues are represented in orange spheres with increased radius. Residues whose mutation is associated with cone, cone-rod or macular dystrophies are labelled in bold and framed.