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. 2016 Oct 14;6:35446. doi: 10.1038/srep35446

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Antimicrobial activity of stents in the test and control groups was evaluated at 1 day, and 1, 2, 4, 8, 12, and 24 weeks, after placement. The test was performed by seeding at the initial time only or at weekly intervals. The result showed a significant difference in antimicrobial activity over time in the silicone polymer membranes with and without Ag-P. The test group showed 99.9% antimicrobial activity against E. coli and K. pneumoniae over 24 weeks. In contrast, antimicrobial activity was decreased dramatically after 2 weeks in the control group (A). Images for inoculation of culture media also showed marked antibacterial activity in the test group (B).