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. 2016 Oct 14;6:34143. doi: 10.1038/srep34143

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) Structure of the vault shell, colored in green and pale green for the top and bottom half-vault moieties, respectively. One of the 78 MVP copies forming the particle shown in brown (PDB id: 4JL8)⁶. The left insets show a close up of the MVP-MVP lateral electrostatic interactions mediated by histidines in the R2 (bottom) and R9 (top) domains. The top right inset shows the MVM-MVP lateral electrostatic interactions in the shoulder domain. The right bottom inset shows the R1-R1 interactions established at the half-vault interface.