Figure 12. Schematic model representing the potential translocation of DnaK and EfTu through the membrane of S. epidermidis, thus leading to recognition of CGRP and Substance P.

DnaK and CGRP are probably translocated in the periplasmic compartment through the MscL channel. CGRP and Substance P are binding to DnaK and EfTu, either in the periplasm or after diffusion through the cell wall, thus leading to formation of complexes able to promote the bacterial response through a yet-unknown mechanism. Competition of DnaK and EfTu for the same transporter may explain the antagonistic effects of CGRP and Substance P.