Table 1. Proteins over-expressed in the secretome of CGRP-treated S. epidermidis identified by MALDI-TOF/TOF.
Spot | NCBI accession Number | Gene Name | Putative function | Mascot score | Number of matched peptides | Coverage (%) | Mass (Da) & pI |
---|---|---|---|---|---|---|---|
1 | WP_002435425.1 | Dihydrolipoyl dehydrogenase | Pyridine nucleotide-disulphide oxidoreductase fold NAD(P)(+)-binding proteins | 107 | 16 | 41 | 49733/4.72 |
2 | WP_002434485.1 | Inosine-monophosphate dehydrogenase | The catalytic domain of the inosine-monophosphate dehydrogenase (IMPDH). IMPDH catalyzes the NAD-dependent oxidation of inosine 5′-monophosphate (IMP) to xanthosine 5′monophosphate (XMP) | 100 | 21 | 43 | 52493/5.35 |
3 | WP_002453341.1 | Superoxidase dismutase | Inorganic ion transport and metabolism | 108 | 15 | 71 | 22697/5.04 |
4 | WP_002435927.1 | Immunodominant surface antigen B (isaB) | Immune response during septicemia: generally classified as a virulence factor (increased expression in vivo during human sepsis) | 98 | 10 | 62 | 20088/4.84 |
5 | WP_002432778.1 | Alkaline shock protein 23 | Alkaline pH tolerance | 120 | 18 | 72 | 19187/4.91 |
6 | WP_002434679.1 | Citrate synthase | CoA binding site: oxalate citrate binding site catalytic triad | 144 | 24 | 55 | 42519/5.26 |
7 | WP_049427550.1 | DnaK | Chaperone: functions in stress- induced protein refolding and degradation | 242 | 43 | 72 | 66071/4.54 |
8 | WP_002436880.1 | Immunodominant antigen B (isaB) precursor | IsaB pro-protein | 101 | 8 | 41 | 18400/5.54 |
9 | WP_030061284.1 | Peroxidoxin | Controls cytokine-induced peroxide levels: confers protection to cells | 141 | 13 | 91 | 21268/4.5 |