Table 3. CASR rs7652589 genotype and allele frequencies in HD patients with serum PTH >500 pg/mL and remaining HD patients.
| CASR rs7652589 | HD patients with serum PTH >500 pg/ml | HD patients serum PTH ≤ 500 pg/ml | Odds ratio (95% CI) | P value | Ptrend | Pgenotype |
|---|---|---|---|---|---|---|
| (n, frequency) | (n, frequency) | |||||
| n = 442 | n = 720 | |||||
| GG | 153 (0.35) | 272 (0.38) | Reference | — | 0.035 | 0.035 |
| AG | 208 (0.47) | 356 (0.49) | 1.039 (0.800–1.350) | 0.8 | ||
| AA | 81 (0.18) | 92 (0.13) | 1.565 (1.094–2.240) | 0.018a | ||
| AA+AG vs GG | 289 (0.65) | 448 (0.62) | 1.147 (0.896–1.468) | 0.3 | ||
| AA vs AG+GG | 361 (0.82) | 628 (0.87) | 1.532 (1.106–2.121) | 0.01 | ||
| MAF | (0.42) | (0.38) | 1.200 (1.011–1.424) | 0.041 | ||
| P for HWE | 0.486 | 0.141 |
Abbreviations: HD, haemodialysis; HWE, Hardy-Weinberg equilibrium; MAF, minor allele frequency; PTH, parathyroid hormone.
aNot significant after the Bonferroni correction.