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. 2016 Jan 4;36(9):1137–1149. doi: 10.1002/jat.3278

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Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Journal of Applied Toxicology published by John Wiley & Sons, Ltd.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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The module for the specific histopathology endpoints has the highest Matthews correlation coefficient (MCC). Shown are the MCCs for the liver histopathology assessments, ordered according to Table 1 from cytoplasmic alteration as P1 to single cell necrosis as P11, and 11 modules for the liver, LM1 to LM11. LM1 corresponds to the module for liver P1 and has the highest MCC for that histopathology. Also shown are the MCCs for the eight kidney injuries, ordered as listed in Table 2. As with the liver modules, KM1 is the module for kidney P1 and has the highest MCC for P1.