Figure 7.

The activation of the modules is organ‐specific. Allopurinol and puromycin, two nephrotoxicants that cause a number of kidney injuries, including kidney fibrosis, generally activate kidney modules. Conversely, thiocetamide, a hepatotoxicant that causes liver fibrosis among other liver injuries, selectively activates liver injury modules. Also shown is carbon tetrachloride, a known hepatotoxicant. The four other chemicals causing liver fibrosis are shown in Supplementary Material Fig. S3.