Table 4.
Linear regression of the activation score relative to the histopathology grade or severity
| Histopathology | Module ID | R 2 |
|---|---|---|
| Liver | ||
| Alteration (cytoplasmic) | LM1 | 0.90 |
| Alteration (nuclear) | LM2 | 0.73 |
| Anisonucleosis | LM3 | 0.15 |
| Cellular infiltration | LM4 | 0.56 |
| Foci (cellular) | LM5 | 0.43 |
| Granular degeneration (eosinophilic) | LM6 | 0.23 |
| Fibrosis | LM7 | 0.57 |
| Hematopoiesis | LM8 | 0.09 |
| Proliferation (bile duct) | LM9 | 0.34 |
| Proliferation (oval cell) | LM10 | 0.68 |
| Single cell necrosis | LM11 | 0.36 |
| Kidney | ||
| Cast (hyaline) | KM1 | 0.26 |
| Cellular infiltration | KM2 | 0.63 |
| Degeneration | KM3 | 0.16 |
| Dilatation | KM4 | 0.62 |
| Fibrosis | KM5 | 0.64 |
| Hypertrophy | KM6 | 0.04 |
| Intracytoplasmic inclusion body | KM7 | 0.65 |
| Necrosis | KM8 | 0.20 |
R2 = coefficient of determination. The histopathology assessments were converted to scores (minimal = 1, slight = 2, moderate = 3, and severe = 4) and averaged over all replicates in a condition. The R2 was determined through linear regression of the averaged histopathology grade and the activation of the module by the positive instances of the injury.