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. 2015 Dec 31;56(7):835–844. doi: 10.1002/jcph.668

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© 2015, The Authors. The Journal of Clinical Pharmacology Published by Wiley Periodicals, Inc. on behalf of American College of Clinical Pharmacology

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Pairwise scatter plots of ΔΔDAS28 between early and late time points. In each plot the symbols represent the observed ΔΔDAS28 at a later time point (specified at the far right end of each row) vs an early time point (specified at the top of each column). Symbol size reflects the sample size of each treatment arm. Unity (dashed) lines represent equal efficacies at the early and late time points; points above suggest a higher efficacy at a late time point, and points below suggest a higher efficacy at an early time point. DAS28, disease activity score in 28 joints.