Table 1.

Developmental- and treatment-specific changes of corticosteroid-related genes in larval fish.

Relative mRNA abundance (AU)
	Hours post fertilisation	igf						fkbp5
	Con	Dex	Con Mo	GR Mo	Hyp con	Hyp	Con	Dex	Con Mo	GR Mo	Hyp con	Hyp
72	1.76±0.06	2.34±0.18	1.77±0.03	0.98±0.02**	1.67±0.01	0.87±0.04	6.0±1.1	11.3±1.21*	5.57±1.79	3.50±0.96	5.98±2.6	4.0±1.9
120	2.76±0.30	2.43±0.30	2.67±0.03	1.24±0.5***	2.77±0.07	0.8±0.1	9.0±2.2	14.00±0.50*	9.34±1.9	3.77±0.95*	8.97±1.1	9.50±2.57
	gr						mr
	Con	Dex	Con Mo	GR Mo (splice)	Hyp con	Hyp	Con	Dex	Con Mo	GR Mo	Hyp con	Hyp
72	1.04±0.06	1.09±0.01	1.02±0.01	0.41±0.01***	1.00±0.06	0.90±0.04	0.41±0.04	0.74±0.06*	0.39±0.1	0.35±0.08	0.40±0.1	0.33±006
120	0.97±0.03	0.96±0.04	1.04±0.06	0.71±0.03*	1.02±0.1	1.24±0.12	0.76±0.02	1.07±0.06**	0.70±0.1	0.59±0.04	0.69±0.1	0.64±0.2
	hsd11b2						cyp11c1
	Con	Dex	Con Mo	GR Mo	Hyp con	Hyp	Con	Dex	Con Mo	GR Mo	Hyp con	Hyp
72	0.91±0.09	1.27±0.01**	0.93±0.03	0.99±0.1	0.99±0.3	0.95±0.04	1.60±0.06	1.80±0.09	1.65±0.01	0.60±0.05	1.7±0.09	1.53±0.01
120	0.76±0.08	1.38±0.09**	0.80±01	1.03±0.05*	0.87±0.12	0.83±0.1	1.79±0.1	1.04±0.04	1.56±0.9	0.70±0.01	1.80±0.04	1.80±0.09

Relative mRNA abundance of genes in larvae treated with (a) dexamethasone, (b) hypoxia and (c) in GR morpholino at 72 and 120hpf. Results were analysed by two-way ANOVA. Effects of time are described in the text. Significant effects of experimental treatment vs respective controls at each time point are *P < 0.05, **P < 0.01 and ***P<0.001 (n= 6–8 groups of 10 fish).