Table 2.
Newly identified HLA alleles with new nucleotide variations
| Alleles with novel changes | Codon numbera | Regular amino acid | Regular codonb | New amino acid | New codonb | Type of mutation |
|---|---|---|---|---|---|---|
| A*01:01:64 | 83 | Glycine | GGC | Glycine | GGT | Synonymous |
| A*01:165 | 133 | Tryptophan | TGG | Cysteine | TGC | Nonsynonymous |
| A*02:01:112 | 83 | Glycine | GGC | Glycine | GGT | Synonymous |
| B*41:34 | 106 | Aspartic Acid | GAC | Alanine | GCC | Nonsynonymous |
| B*44:02:33 | 92 | Serine | TCT | Serine | TCC | Synonymous |
| B*46:59 | 157 | Arginine | AGA | Lysine | AAA | Nonsynonymous |
| C*04:179 | 16 | Glycine | GGC | Aspartic Acid | GAC | Nonsynonymous |
| C*04:192 | 73 | Threonine | ACT | Aspartic Acid | GAT | Nonsynonymous |
| C*06:02:34 | 20 | Proline | CCC | Proline | CCG | Synonymous |
| C*06:151 | 132 | Serine | TCC | Proline | CCC | Nonsynonymous |
| C*07:334 | 89 | Glutamic Acid | GAG | Glycine | GGG | Nonsynonymous |
| C*07:376 | 23 | Isoleucine | ATC | Threonine | ACC | Nonsynonymous |
| DQB1*02:44 | 64 | Glutamine | CAG | Lysine | AAG | Nonsynonymous |
| DQB1*03:102 | 52 | Proline | CCG | Alanine | GCG | Nonsynonymous |
| DQB1*05:01:15 | 67 | Valine | GTC | Valine | GTT | Synonymous |
| DQB1*05:68 | 43 | Aspartic Acid | GAC | Asparagine | AAC | Nonsynonymous |
| DQB1*06:04:10 | 67 | Valine | GTC | Valine | GTA | Synonymous |
| DPB1*02:01:17 | 52 | Glycine | GGG | Glycine | GGA | Synonymous |
| DPB1*03:01:04 | 49 | Threonine | ACG | Threonine | ACA | Synonymous |
| DPB1*04:01:11 | 84 | Glycine | GGC | Glycine | GGA | Synonymous |
| DPB1*04:01:13 | 25 | Leucine | CTG | Leucine | TTG | Synonymous |
| DPB1*04:01:14 | 15 | Cysteine | TGC | Cysteine | TGT | Synonymous |
| DPB1*04:01:27 | 82 | Glutamic Acid | GAG | Glutamic Acid | GAA | Synonymous |
| DPB1*04:02:05 | 42 | Valine | GTG | Valine | GTT | Synonymous |
| DPB1*05:01:05 | 31 | Asparagine | AAC | Asparagine | AAT | Synonymous |
| DPB1*14:01:02 | 34 | Glutamic Acid | GAG | Glutamic Acid | GAA | Synonymous |
| DPB1*169:01 | 18 | Phenylalanine | TTT | Valine | GTT | Nonsynonymous |
| DPB1*180:01 | 63 | Lysine | AAG | Threonine | ACG | Nonsynonymous |
| DPB1*186:01 | 80 | Asparagine | AAC | Serine | AGC | Nonsynonymous |
| DPB1*187:01 | 77 | Cysteine | TGC | Phenylalanine | TTC | Nonsynonymous |
| DPB1*193:01 | 25 | Leucine | CTG | Valine | GTG | Nonsynonymous |
| DPB1*194:01 | 24 | Phenylalanine | TTC | Leucine | TTG | Nonsynonymous |
| DPB1*195:01 | 22 | Glutamine | CAG | Arginine | CGG | Nonsynonymous |
| DPB1*212:01 | 20 | Glycine | GGG | Arginine | AGG | Nonsynonymous |
| DPB1*216:01N | 78 | Arginine | AGA | Stop | TGA | Nonsense |
| DPB1*222:01 | 26 | Glutamic Acid | GAG | Valine | GTG | Nonsynonymous |
| DPB1*298:01 | 23 | Arginine | CGC | Serine | AGC | Nonsynonymous |
| DPB1*323:01 | 19 | Asparagine | AAT | Serine | AGT | Nonsynonymous |
| DPB1*325:01 | 53 | Arginine | CGG | Tryptophan | TGG | Nonsynonymous |
| DPB1*329:01 | 21 | Threonine | ACA | Isoleucine | ATA | Nonsynonymous |
| DPB1*336:01 | 50 | Glutamic Acid | GAG | Glutamine | CAG | Nonsynonymous |
| DPB1*360:01 | 22 | Glutamine | CAG | Leucine | CTG | Nonsynonymous |
| DPB1*376:01 | 52 | Glycine | GGG | Glutamic Acid | GAG | Nonsynonymous |
| DPB1*404:01 | 25 | Leucine | CTG | Glutamine | CAG | Nonsynonymous |
| DPB1*407:01 | 38 | Phenylalanine | TTC | Leucine | TTA | Nonsynonymous |
| DPB1*420:01 | 81 | Tyrosine | TAC | Cysteine | TGC | Nonsynonymous |
| DPB1*425:01 | 38 | Phenylalanine | TTC | Leucine | TTA | Nonsynonymous |
| DPB1*426:01 | 48 | Valine | GTG | Methionine | ATG | Nonsynonymous |
| DPB1*435:01 | 14 | Glutamic Acid | GAA | Glycine | GGA | Nonsynonymous |
a
Numbering starts from the first codon of the mature protein.
b
Codon alterations are printed in bold.